Novel approaches to predictive toxicology; assimilating and fusing information on nanomaterial-biological interactions to permit data mining, generate predictive knowledge and provide information to minimize toxicity; the relationships among currently disparate exposure, dose and toxicity data in animal systems (including humans) and the degree to which those relationships can accurately be extrapolated to other systems and exposure scenarios; novel tools to determine nanomaterial characteristics; biological activity and toxic potential of novel nanomaterials; as well as comparative physiology and toxicology
