Our laboratory is interested in understanding how structures and dynamics of gene regulatory networks have evolved to regulate complex phenotypes. We focus primarily on microbial systems due to the relative simplicity of microbial genomes, which allow us to interrogate complex processes across a wide range of levels of cellular complexity (e.g. from single proteins to comprehensive systems-level analysis). We aim to develop tools that will allow the rational engineering of gene regulatory networks at both the protein and network-structure levels, and have application across species boundaries
