Frantziskonis’s areas of research interests and activities include multi-and inter-disciplinary multiscale modeling, simulation, and experimentation, material characterization and applications, probabilistic and multiscale problem formulation and description and applications to safety and reliability, behavior of materials at nano-scale, reaction-diffusion-transport and reactive flow problems, smart materials at a multiplicity of scales. Applications include material characterization and modeling, response of materials to rare stochastic events, and reaction-diffusion-transport phenomena in energy production processes. He has published extensively in journals in the areas of (some journals where his work has been published are shown in parentheses), the diversity coming primarily from extending multiscale methods to several areas of science and engineering