Dr. Jain directs the Bioinspired Translational Microsystems (BioinSyst) lab that specializes in making patient-specific and digital microengineered models of cardiovascular and hematologic diseases for enabling basic discovery and advancing smart analytical technologies for precision and personalized health care.
The overarching theme of Dr. Jain’s interdisciplinary lab is to harness the basic knowledge and tools offered by cell and molecular biology, biomechanics, microfabrication technology, biomaterials, and mathematics, in order to reconstruct the in vivo functionality of human tissues and organs in microfluidic devices (organs-on-chip), where the solid and fluid forces can be reconstituted at physiological spatial and temporal scales. Importantly, the observations made by analyzing the complex intercellular signaling are digitized so that these synthetic organs are transformed into automated sensors and actuators for translational applications.
The BioinSyst lab is currently specifically focused in the hemodynamics within organs-on-chip and reproduce pathophysiological interactions between the blood cells and the vessel wall (endothelium) under flow to derive a systems biology perspective of the vascular system. These efforts are leading to the development of novel diagnostic and clinically-relevant microsystems that assess vascular and platelet function, hemostasis and thrombosis.
